Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch.

JCI Insight · 2021 · PMC8525639 · PMID 34622803

Europe PMC DOI

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0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approached significanceP = 0.06so close (0.05 < p ≤ 0.1)

In contrast, MK2i-NP 50:2.5Lyo -treated cells displayed markedly diminished p-CREB levels at day 7 after treatment (45% reduced) and day 10 (38% reduced), although p-CREB diminution at day 10 only approached significance ( P = 0.06) (full statistics in Supplemental Table 3 ).

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