CD8+ T lymphocytes are sensitive to NKG2A/HLA-E licensing interaction: role in the survival of cancer patients.

Although no significant results were observed in the log-rank test, a clear trend toward better OS was observed in a −21 M dose-dependent way for all cancer patients and for each type of cancer including solid cancer (melanoma, bladder and ovarian carcinomas), plasma cell neoplasm and childhood acute leukemia ( Figure 3 ).

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The highly significant CD226 increase observed in the corresponding NK cell subsets in the presence of their specific C1, C2, Bw4 and −21 M ligands suggests that both education pathways are active in the NK cells of cancer patients.

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