Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the <i>Ube3a</i> Deletion Rat Model of Angelman Syndrome.

Elevated 50 kHz calling by Ube3a mat–/pat+ was also specific to being provoked by heterospecific play, as 50 kHz and short 22 kHz USV production was normal during exploration of an empty cage (albeit a slight trend toward more 50 kHz USV; Fig. 1 H ; 50 kHz, U = 374.5, p > 0.05; 22 kHz, U = 433, p > 0.05, d = 0.56) and in response to the acoustic presentation of 50 kHz USVs ( Fig. 1 I ; 50 kHz, U = 53, p > 0.05; 22 kHz, U = 44.50, p > 0.05).

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Ube3a mat–/pat+ rats showed a trend toward reduced corpus callosum volume (−6.7%), but the largest white matter deficits were cerebellar.

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