Second-generation antipsychotic use during pregnancy and risk of congenital malformations.

Eur J Clin Pharmacol · 2021 · PMC8528770 · PMID 34100993

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marginally significantno p-value reported

Of the individual drugs, only risperidone use (> 1500 pregnancies) was associated with an increased risk of overall malformations (OR 1.26; 95% CI 1.02–1.56) and a marginally significant risk of cardiac malformations (OR 1.26; 95% CI 0.88–1.81) [ 6 ].

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did not reach statistical significanceno p-value reported

Of the individual S-GAs, olanzapine use was associated with an increased risk of any MCM when compared to F-GA users, but did not reach statistical significance.

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