MicroRNA expression in animal models of amyotrophic lateral sclerosis and potential therapeutic approaches.

By qRT-PCR, a highly significant upregulation of miR-29b-3p was found in the spinal cord of wobbler mice at 0 days of age, and a highly significant downregulation at 40 days of age.

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While male mice treated with miR-29a antagomir showed a trend towards increased lifespan, female mice had no change in lifespan following treatment with miR-29a antagomir.

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