Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.

Mol Ther · 2021 · PMC8531145 · PMID 34058387

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Knockdown of NKCC1 with both amiRs showed a trend toward a decrease in the percentage of spontaneously active CA1 neurons in Ts65Dn mice, although that was not statistically significant ( Figure 5 B).

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