Impact of Silibinin A on Bioenergetics in PC12APP<sub>sw</sub> Cells and Mitochondrial Membrane Properties in Murine Brain Mitochondria.

Antioxidants (Basel) · 2021 · PMC8533090 · PMID 34679655

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a small trendno p-value reported

The effect on coupling in PC12APP sw was limited at best ( p = 0.69), showing only a small trend for altered coupling, suggesting that OXPHOS was unaffected by the transfection.

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showed a trendno p-value reported

Using TMA-DPH, a fluorescent dye that imbeds itself into outer, hydrophilic regions of the phospholipid layer, we found that 50 μM SIL showed a trend and 100 μM SIL significantly increased membrane fluidity ( p < 0.0004) which is inversely correlated to the measured anisotropy.

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