Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion.

Cells · 2021 · PMC8534202 · PMID 34685500

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highly significantno p-value reported

Of the three cell lines, S411 cells responded most strongly and highly significant with a G2/M phase arrest to 5 μM irinotecan after 24 h.

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did not reach statistical significanceno p-value reported

This is consistent with the inhibition of RRM2 by hydroxyurea, but its effects on G2/M phase did not reach statistical significance after 24 h.

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