Transcriptomic Biomarkers for Tuberculosis: Validation of <i>NPC2</i> as a Single mRNA Biomarker to Diagnose TB, Predict Disease Progression, and Monitor Treatment Response.

Cells · 2021 · PMC8534371 · PMID 34685683

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

borderline significancep = 0.057so close (0.05 < p ≤ 0.1)

For the South African cohort, we observed a significant decrease ( p = 0.0037, Figure 5 F) in NPC2 levels during treatment, with a borderline significance ( p = 0.057, Figure 5 C) for the Chinese cohort.

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showed a trendno p-value reported

Interestingly, after month 6 of exposure, expression of all three mRNA showed a trend toward normalization in non-progressors, although a significant difference was only observed for NPC2 (as indicated by the significant down-regulation between the dashed and dotted white bars in Figure 4 C).

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