Maturation of the Visceral (Gut-Adipose-Liver) Network in Response to the Weaning Reaction versus Adult Age and Impact of Maternal High-Fat Diet.

Biopsy data in the available samples demonstrated a significant trend of steatohepatitis grades, worsening across the four age*maternal-diet subgroups ( Figure 1 J), supporting a summative contribution of age and maternal HFD, in which adult HFDoff had the most severe liver condition with a 40% elevation in circulating triglyceride levels (1.15 ± 0.10 vs. 0.79 ± 0.00 mmol/L, p < 0.003 vs. adult NDoff).

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Effect of Age The RDA analyses showed highly significant differences in the microbiota profile between weaning and adult age in both the caecum and colon ( Figure 2 A).

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