Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury.

J Cereb Blood Flow Metab · 2021 · PMC8545055 · PMID 34259069

Europe PMC DOI

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0.0590

closest p · 1.2× alpha

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a strong trendp = 0.0590so close (0.05 < p ≤ 0.1)

However, IL-4-treated TBI PPARγ OPC-cKO mice showed significantly improved cognitive performance (Supplemental Figure 2(b) to (d), Escape latency, p < 0.0001; Quadrant time, p = 0.0321) or a strong trend toward improvement in spatial memory (Supplemental Figure 2(d), Platform crossings, p = 0.0590) compared to vehicle-treated TBI mice.

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