mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status.

This was confirmed by our detection of higher expression of CD127, CXCR4, and CCR7 on spike-specific CD4+ T cells from the convalescents, although for CXCR4 the difference did not reach statistical significance ( Figure 5—figure supplement 1B ).

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