Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature.

In particular, IS was positively correlated with HAM-A psychic subscore in the females ( r = 0.32, p = 0.002) and the males, but the correlation in the male group did not reach statistical significance ( r = 0.28, p = 0.071).

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