<i>SLAMF8</i> expression predicts the efficacy of anti-PD1 immunotherapy in gastrointestinal cancers.

We also validated the significant and positive association between the mRNA expression of SLAMF8 and CD8A in our RNA‐sequencing data of CRC with 20 tissue samples (Figure 3 a and b, P = 0.005), but we only observed borderline significance (Figure 3 c and d, P = 0.089) for this association in the RNA‐sequencing data of 19 GC tissue samples, probably because of the limited sample size.

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Quantitative analysis further demonstrated a higher pretherapeutic expression of SLAMF8 in the sensitive group than in the resistant group (Figure 4 c, P = 0.009), but the difference in the expression levels of CD8 did not reach statistical significance, likely induced by the limited sample size (Figure 4 d, P = 0.1654).

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