Roles of Surgery in the Treatment of Patients With High-Risk Neuroblastoma in the Children Oncology Group Study: A Systematic Review and Meta-Analysis.

GTR or CTR resection had significantly better 5-year OS [p = 0.45; HR = 0.56 (95% CI, 0.43–0.72); I 2 = 0%] and 5-year EFS [ p = 0.15; HR = 0.80 (95% CI, 0.71–0.90); I 2 = 31%] than subtotal tumor resection (STR) or biopsy only; however, both CTR or GTR showed a trend for more intra and post-operative complications compared with the STR or biopsy only [ p = 0.37; OR = 1.54 (95% CI, 1.08–2.20); I 2 = 0%].

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