The Application of CRISPR/Cas Systems for Antiviral Therapy.

Front Genome Ed · 2021 · PMC8549726 · PMID 34723245

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did not reach statistical significanceno p-value reported

A study in liver-humanized mice using the smaller Staphylococcus aureus (Sa) Cas9, delivered by IV AAV, was able to improve survival of human hepatocytes, although reduction in HBV cccDNA did not reach statistical significance ( Stone et al., 2021 ).

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