Association between a 46-SNP Polygenic Risk Score and melanoma risk in Dutch patients with familial melanoma.

A comparison between cases with the highest 10% FCS (high-density melanoma families, n=42) and cases with the lowest 10% FCS (low-density melanoma families, n=39) revealed that cases from low-density melanoma families had a higher mean sPRS (0.94, 95% CI 0.55 to 1.33) than cases from high-density melanoma families (0.60, 95% CI 0.25 to 0.95) ( table 2 ) , although this difference did not reach statistical significance (p=0.204).

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Finally, our PRS model was based on a refined selection of 46 highly significant SNPs that have been repeatedly identified in large independent GWA studies.

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