Kahweol (20 μg/paw) did not reach statistical significance, but 40 and 80 μg/paw were significant at 5 and 20 min after kahweol injection, and at 5 min, there was statistical significance between the doses of 40 and 80 μg/paw.
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Kahweol, a natural diterpene from coffee, induces peripheral antinociception by endocannabinoid system activation.
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