Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine.

Sci Adv · 2021 · PMC8555896 · PMID 34714668

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did not reach statistical significanceno p-value reported

The inclusion of QS21, which is known to broaden the immune response and enhance cell-mediated immunity ( 38 ), induced high levels of spike-specific IFN-γ – secreting T cells and increased the magnitude of RBD- and NTD-specific antibodies, although this did not reach statistical significance compared to nonadjuvanted HD-MAP spike.

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