Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells.

While the expression of COL2A1 only showed a trend towards lower expression (FD = −17.2, P = 9.0 × 10 −2 ), significantly lower levels of matrix gene ACAN (FD = −21.8, P = 1.1 × 10 −2 ) and chondrogenic transcription factor SOX9 (FD = −3.9, P = 2.6 × 10 −2 ) were expressed in hiMSC-derived neo-cartilage compared to that from hBMSCs.

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