High mutations in fatty acid metabolism contribute to a better prognosis of small-cell lung cancer patients treated with chemotherapy.

In the following multivariate Cox regression, when the influence of clinical factors such as tumor stage, sex, age, and smoking was excluded, this pathway also showed a trend to be prognostic (HR = 0.315, 95% CI, 0.098–1.018, p = 0.054). 3.6 Mutations in the FA metabolism pathway affect the responsiveness of SCLC cell lines to some drugs Next, we explored the correlation between the frequency of mutations in FA metabolism pathways and the responsiveness of SCLC cell lines to compounds in the GDSC database.

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