Bidirectional regulation of calcium release-activated calcium (CRAC) channel by SARAF.

Indeed, although we had previously found a small decrease in the magnitude of I CRAC s following RNAi-mediated knockdown of SARAF expression in Jurkat T cells ( Palty et al., 2012 ), that difference did not reach statistical significance, and additional studies in HEK293 cells did not report a change in current densities when expression of endogenous SARAF was reduced ( Jha et al., 2013 ; Lopez et al., 2019 ; Maléth et al., 2014 ).

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