As anticipated, young RMs showed significantly higher baseline frequencies of total CD4 ( P = 0.0047) ( Supplemental Figure 1D ), and they showed a trend of higher CD4 and CD8 naive (CD28 + CD95 – ) subsets compared with old RMs ( Supplemental Figure 1 , E and I).
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IL-21 enhances influenza vaccine responses in aged macaques with suppressed SIV infection.
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