Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer.

Genome Med · 2021 · PMC8567649 · PMID 34732240

Europe PMC DOI

hedged sentences

0.0410

closest p · 0.8× alpha

0.0940

boldest claim

The sentences

a pronounced trendp = 0.041actually significant

Notably, the patients with high HLA-B HED showed a pronounced trend towards prolonged OS (Fig. 3c , log-rank test p = 0.041) and PFS (Fig. 3d , log-rank test p = 0.18).

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a definite trendp = 0.094so close (0.05 < p ≤ 0.1)

5c , p < 0.05) and the differential mutational frequency of TP53 showed a definite trend (Fig. 5e , p = 0.094).

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did not reach statistical significanceno p-value reported

3b , log-rank test p = 0.25), although the difference did not reach statistical significance.

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a positive trendno p-value reported

did not quite achieve the threshold for statistical significanceno p-value reported

Intriguingly, in the MSI-H patients, we observed a positive trend of association between HLA-B HED and TMB or TNB, although the correlation coefficient did not quite achieve the threshold for statistical significance with the limited sample size.

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