Epigenetic adaptations of the masticatory mucosa to periodontal inflammation.

At the PTP4A3 locus, such an approach would result in a highly significant p value with a ∆ β of − 0.07 (calculated from the raw β = 0.87 in clinically uninflamed and 0.8 in inflamed tissue).

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Likewise, we observed that of the top 10 associated DMPs (best q = 4.5 × 10 –16 at cg19478962, locating to the noncoding RNA gene LOC643339 ), only three showed nominally significant associations in a sub-analysis of the 39 individuals for whom an uninflamed and inflamed sample each was available for the EWAS.

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