ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers.

Invest Ophthalmol Vis Sci · 2021 · PMC8572510 · PMID 34727153

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hedged sentences

0.0000

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantP = 1.29E-06actually significant

When combining samples carrying the four co-susceptibility alleles A29, A30, A31, and A33, we found a highly significant enrichment in BSCR cases when compared with the larger control cohorts (GHS cohort 1, P = 1.29E-06; GHS cohort 2, P = 1.07E-06; UKB, P = 9.62E-07) ( Table 1 , top row).

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nominally significantP = 0.1so close (0.05 < p ≤ 0.1)

HLA-A32 Exhibits Protection from BSCR in an HLA-A29 Positive Cohort HLA-A32 is underrepresented in BSCR cases (3/286, ∼1%) compared with A29 carrier controls (4/108, 3.7%), corresponding to a nominally significant protection from risk (OR = 0.28; P = 0.1) ( Table 1 ).

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