This can play a quite significant protective role, considering more tissue injury may occur via this indirect mechanism of radiation than by the initial direct DNA damage. 32 , 33 We investigated how DFO would affect this process by testing several downstream effects of pathologic oxidation. 8‐Iso, an arachidonic acid metabolite and isoform of naturally occurring prostaglandin F2alpha, is a product of lipid peroxidation.
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A comparative analysis of deferoxamine treatment modalities for dermal radiation-induced fibrosis.
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