Environmental Risk Factors for Endometriosis: An Umbrella Review of a Meta-Analysis of 354 Observational Studies With Over 5 Million Populations.

A recent report have demonstrated that all burden estimates of endometriosis have decreased on a global basis, however, the incidence, prevalence, and the number of years of life lived with disability, associated with this disease, exhibited an increasing trend in countries with a high sociodemographic index between 1990 and 2017 ( 2 ).

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Evaluation of the Excess Significance We calculated excess significance bias by investigating whether the observed (O) number of nominally significant findings was significantly different from the expected (E) number of statistically significant studies.

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