Viral alpha-synuclein knockdown prevents spreading synucleinopathy.

Brain Commun · 2021 · PMC8576194 · PMID 34761222

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0900

boldest claim

The sentences

did not quite achieve significanceP = 0.052so close (0.05 < p ≤ 0.1)

Our results indicated a protective effect of miR-SNCA at 65 days ( t = 2.19, P = 0.047) and 86 days ( t = 2.313, P = 0.032), but did not quite achieve significance at 100 days ( t = 2.078, P = 0.052) after excluding an animal in the eGFP cohort that had reached clinical endpoint.

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did not reach statistical significanceP = 0.09so close (0.05 < p ≤ 0.1)

Despite a trend to lower total α-syn levels in striata of miR-SNCA versus eGFP-treated animals, the difference did not reach statistical significance (−24%, P = 0.09; Fig. 6A ), consistent with the weak eGFP expression in the caudal region of the striatum shown in Fig. 1J .

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