Slit2-Mediated Metabolic Reprogramming in Bone Marrow-Derived Macrophages Enhances Antitumor Immunity.

Front Immunol · 2021 · PMC8581492 · PMID 34777365

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While tumors from Slit2-treated mice only showed a trend in decrease in the M2 macrophage population (data not shown), M1 macrophages identified as CD45+F4/80+CD38+ cells were significantly more abundant in mice with Slit2-treated tumors compared to PBS-treated tumors (71 ± 20 vs. 188 ± 81.4 cells in 20,000 events, n = 4, *p < 0.05) ( Figure 1B ).

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