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Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person.

EPMA J · 2021 · PMC8581606 · PMID 34786033

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a clear trendno p-value reported
A genetic predisposition to the altered Hcy metabolism may play a role, since there is a clear trend toward the worldwide prevalence of MTHFR 677 T and COVID-19 incidence and mortality.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.