From a methodological perspective on GWAS analyses, our practical approach is supported by investigations demonstrating nominally significant results occurring significantly less often than expected for low-MAF SNVs, resulting in a conservative bias [ 54 , 55 ].
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Genetic Variation in <i>ABCC4</i> and <i>CFTR</i> and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia.
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In the second approach, 13 highly significant SNVs were identified ( Table 3 ; Figure 1 and Figure S4 ).