Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength.

Immunity · 2021 · PMC8585507 · PMID 34534438

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.1531

boldest claim

The sentences

highly significantp = 0.00097actually significant

For the Ipi-N cohort, this increase in TCR.strong score was highly significant (p = 0.00097) in those with evidence of clinical benefit, which was not captured by the T cell activation metric ( Figure 7 D).

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a strong trendp = 0.1531not close (p > 0.1)

Analysis of the TCR.strong metric in the Ipi-N cohort of patients showed increases in those with clinical responses (p = 0.0105) and a strong trend in patients from the Ipi-P group (p = 0.1531, Figure 7 C).

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