Relationship between cytokines and brain-derived neurotrophic factor (BDNF) in trajectories of cancer-related cognitive impairment.

Cytokine · 2021 · PMC8585614 · PMID 33985854

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did not reach statistical significanceno p-value reported

The interactions between other impairment trajectories and other cytokines did not reach statistical significance.

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an overall trendno p-value reported

There was an overall trend of circulating cytokine increase, indicative of gross peripheral immune activation by chemotherapy, and a significant decline in BDNF levels throughout chemotherapy.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.