Role of Runx2 in Calcific Aortic Valve Disease in Mouse Models.

The calculated AVA, as determined by the continuity equation, showed a trend toward improvement in the T2DM fed LDLr −/− ApoB 100 Runx2 ΔSMA mice (~20%) compared with LDLr −/− ApoB 100 Runx2 f/f ( p = 0.13) However, no statistically significant difference was observed between the three groups ( Figure 5 ).

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A decreasing trend was noted in the valve cusps of LDLr −/− ApoB 100 Runx2 ΔSMA compared with that of the LDLr −/− ApoB 100 Runx2 f/f valves, but this did not attain statistical significance.

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