Overall, we observed strong overlap between gene expression changes in qNSCs versus aNSCs in all systems ( in vivo NSCs, in vitro NS5 cells, and NSPCs), although comparison of genes downregulated in aNSCs versus qNSCs in vivo and in our primary culture did not reach statistical significance.
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Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation and is altered with age.
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