Detrimental proarrhythmogenic interaction of Ca<sup>2+</sup>/calmodulin-dependent protein kinase II and Na<sub>V</sub>1.8 in heart failure.

Nat Commun · 2021 · PMC8593192 · PMID 34782600

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0.0800

closest p · 1.6× alpha

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boldest claim

The sentences

a strong trendp = 0.08so close (0.05 < p ≤ 0.1)

Blinded analysis revealed that SCN10A −/− /CaMKIIδc +/T showed a strong trend towards a reduction of premature ventricular contractions (PVC) by ~93% compared to CaMKIIδc +/T (Fig. 6a, c , p = 0.08).

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