Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target.

Front Oncol · 2021 · PMC8593415 · PMID 34796107

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0930

boldest claim

The sentences

mildly significantp-value=0.07so close (0.05 < p ≤ 0.1)

A similar trend was seen in the inhouse data but the result was only mildly significant (p-value=0.07) ( Figure 3E , Supplementary Figure S2A ).

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borderline significancep-value=0.093so close (0.05 < p ≤ 0.1)

The rest of the 5 genes, individually, did not show any significant differential survival with respect to presence or absence of mutations ( Supplementary Figures S5A–E ), though BCAP31 showed borderline significance in its Kaplan-Meier plot (p-value=0.093) ( Supplementary Figure S5A ), and a significant difference in survival on clubbing it with TP53 a known tumor suppressor (p=0.031) ( Supplementary Figure S5F ).

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