The interaction term was found to be nominally significant (p-value < 0.05) for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and whole-body water mass, and suggestive (p-value < 0.10) for the basal metabolic rate, all driven by the effects in females ( Figure 6a ).
Identifying the phenotype and environmental pressures that may have caused the selection signal is complicated by the fact that the UK Biobank participants, on which the marginally significant associations have been found, do not live in the same environment as Peruvians.
I'm not very aware of this measure, but I was curious as to whether the other SNPs that have highly significant iHS values are of relevance, and what the interpretation would be here?