Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity.

In contrast, there was a clear trend in which a weaker rear can be amenable to receptor input and lead to a measurable whole-cell response.

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Overall, we found that NSC668394 had no significant effect, whereas Y27632 and nocodozole had highly significant and opposite effects (Fig. 5c ), suggesting that the dominant effect on the rear sensitivity is through the myosin II/RhoA pathway rather than through ERM proteins.

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