Vitamin K₂-a neglected player in cardiovascular health: a narrative review.

112 Moreover, a separate prospective investigation of 40 087 men from the Health Professionals’ Follow-up Study from 1986 to 2000 found a significant trend (RR=0.84, p=0.05) towards a lower incidence of total CAD with increasing intake of food rich in vitamin K 1 . 113 In the prospective PREDIMED (Prevención con Dieta Mediterránea) Study, the authors investigated the impact of dietary vitamin K 1 and K 2 on all-cause mortality among 7216 participants who were followed for a median of 4.8 years. 114 They found a significant and inverse relationship between dietary vitamin K 1 intake and risk of all-cause mortality after controlling for potential confounders (HR=0.64, 95% CI: 0.45 to 0.90).

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