TNF-α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm-ageing.

Specifically, adalimumab‐treated old animals showed reduced Bederson scores already 2 hours after the ischaemic events, a finding consolidating over time being highly significant after 24 and 48 hours of reperfusion ( P < .05 and P < .01, respectively; Figure 5C ).

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Occludin and VE‐cadherin showed a similar trend towards decreased expression in old animals, although in these cases it did not reach statistical significance (Figure 2C‐D ).

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