Epigenetics of alcohol use disorder-A review of recent advances in DNA methylation profiling.

Studies in both postmortem and living human brain tissue have found limited correlations between methylation patterns in the brain and peripheral tissue of patients, with the highest interindividual correlation between nominally significant CpG sites in brain and blood at roughly 20%. 71 , 72 , 73 However, some analyses have shown that the correlation between methylation across brain and blood is stronger at certain CpG sites, and analyses of DNA methylation in blood could focus on these sites. 72 Studies of methylation in brain tissue from AUD cases rely on postmortem cohorts, which usually have a limited number of subjects.

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