A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation.

Elife · 2021 · PMC8598162 · PMID 34747695

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did not reach statistical significanceno p-value reported

In contrast, Cluster five showed a subset of genes that were reduced only in macrophages lacking MED16, including Irf8 and Stat1 ; as these effects were modest, and did not reach statistical significance, they may be suggestive of an incomplete positive feedforward in which MED16 plays a role.

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