HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits.

A priori planned analysis of vehicle data alone revealed that vehicle-treated HIVtg rats exhibited deficient PPI relative to vehicle-treated WT rats (F [1,27] = 4.4, P < .05, η p 2 = 0.14; Figure 3A ), with a near-significant trend toward prepulse × genotype interaction (F [2,54] = 3.1, P = .052, η p 2 = 0.10) suggesting a specificity to 68-dB prepulse conditions (F [1,27] = 5.2, P < .05, η p 2 = 0.16).

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