Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.

Cancer Cell · 2021 · PMC8599450 · PMID 34715028

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showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

We performed clonotype clustering analysis ( STAR Methods ) in the ADAPTeR cohort, and observed that expanded TCR clones showed a trend toward increased clustering of similar CDR3 sequences (or “cluster structure”) in responders compared with non-responders, both pre- and post-treatment (p = 0.06 and 0.07, respectively) ( Figures 5 F and S8 C).

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