The anti-inflammatory adipokine adiponectin was modestly decreased in BMT-APPL1 KO mice when compared to BMT-WT controls under HFD feeding, although it did not reach statistical significance (Supplementary Table 1 ).
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The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages.
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