Association Between CLOCK Gene Variants and Restless Legs Syndrome in Koreans.

Genotyping was performed using reverse transcription polymerase chain reaction and high-resolution melting curve analyses. Results Although the genotype distributions of the CLOCK variants (rs1801260 and rs2412646) were not significantly different between patients with RLS and non-RLS controls, the allele frequencies of CLOCK rs1801260 showed marginally significant differences between the two groups (X 2 =2.98, p=0.085).

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Such difference of marginal significance should be carefully considered when interpreting the results.

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