Hippocampal Function Is Impaired by a Short-Term High-Fat Diet in Mice: Increased Blood-Brain Barrier Permeability and Neuroinflammation as Triggering Events.

GFAP labeling ( Figures 2C,D ) was significantly increased in the hippocampus of mice fed HFD for 4 weeks ( p = 0.0319), whereas the modest increases observed at the earlier time-points did not reach statistical significance ( Supplementary Figure 2C ).

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