Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis.

Pharmacogenomics J · 2021 · PMC8602035 · PMID 34175889

Europe PMC DOI

hedged sentence

0.2140

closest p · 4.3× alpha

0.2140

boldest claim

The sentences

did not reach statistical significancep = 0.214not close (p > 0.1)

Moreover, HLA-B*15:21 allele showed significant association between AEDs-induced SJS/TEN and general Thai population (2/46 (4.3%) vs 2/470 (0.42%), OR 10.636, 95%CI: 1.462–77.359; p < 0.042), while the association between HLA-B*15:21 allele and AEDs-tolerant controls did not reach statistical significance ( p = 0.214).

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